Mérieux Foundation, an independent family foundation with public interest status, has been fighting infectious diseases affecting vulnerable populations in resource-limited countries since its creation in 1967. Operating directly in more than 25 countries, it is committed to strengthening local capacities, particularly in clinical biology, in order to improve access to care, surveillance and response to epidemics. The foundation works side-by-side with local partners and builds networks to mobilize the skills and energies necessary to implement effective and sustainable actions. It is particularly involved in the public health issues that have the greatest impact in the countries where it operates, such as antimicrobial resistance, tuberculosis, acute respiratory infections, HIV, and emerging pathogens. Committed to a global health approach, the Mérieux Foundation goes beyond its expertise in biology to include the main and most impactful issues that influence the well-being of the populations in the countries where it operates.